Candida albicans mannoprotein influences the biological function of dendritic cells
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چکیده
منابع مشابه
Mannoprotein Adhesin of Candida albicans Germ Tubes
469 Abstract: The production and detection of a mannoprotein adhesin (MPA) of the hyphalform cells of C. albicans on plastic petri dishes was investigated. Using Concanavalin A-coated latex microspheres, the MPA was detected on the plastic surface on which C. albicans produced germ tubes. The adhesin was extracted using dithiothreitol and iodoacetamide. It did not inhibit the adhesion of the ye...
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The fungal cell wall is the first point of interaction between an invading fungal pathogen and the host immune system. The outer layer of the cell wall is comprised of GPI anchored proteins, which are post-translationally modified by both N- and O-linked glycans. These glycans are important pathogen associated molecular patterns (PAMPs) recognised by the innate immune system. Glycan synthesis i...
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Intraperitoneal administration of CAWS (water-soluble extracellular polysaccharide fraction obtained from the culture supernatant of Candida albicans) to mice induces coronary arteritis similar to Kawasaki disease. We analyzed differences in the production of cytokines involved in the occurrence of coronary arteritis among mouse strains, C3H/HeN, C57BL/6, DBA/2 and CBA/J. The incidence of arter...
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The functional consequences of treating human monocytes with purified and chemically characterized Candida albicans -glucan—a major microbial pathogen associated molecular pattern—on their differentiation into dendritic cells (DC) were investigated. We show here that -glucan-treated monocytes differentiated into mature DC (Glu-MoDC) with altered phenotype and functional behavior, similarly to D...
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ژورنال
عنوان ژورنال: Cellular Microbiology
سال: 2006
ISSN: 1462-5814,1462-5822
DOI: 10.1111/j.1462-5822.2005.00651.x